Induction of apoptosis (programmed cell death)
Upregulation of Bax (a pro-apoptosis gene)
Downregulation of Bcl-2 proteins (cancer-associated)
Downregulation of prosurvival genes NF-κB, Bcl-X, Mcl-1, and Survivin
Downregulation of cell cycle-regulating proteins, including cyclin D1 and cyclin-dependent kinase-4 (CDK-4). (cancer-associated)
Increased expression of CDK inhibitor, p21 (anti-cancer associated)
Inhibition of c-Myc, hTERT (cancer-associated)
Prostate Cancer [xiii] [xiv] [xv]
[i] Ayman I Elkady, Osama A Abuzinadah, Nabih A Baeshen, Tarek R Rahmy. Differential Control of Growth, Apoptotic Activity, and Gene Expression in Human Breast Cancer Cells by Extracts Derived from Medicinal Herbs Zingiber officinale . J Biomed Biotechnol. 2012 ;2012:614356. Epub 2012 Aug 26. PMID: 22969274
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