Bicarbonate and Dichloroacetate: Evaluating pH Altering Therapies in a Mouse Model for Metastic Breast Cancer
Ian F Robey 1 * and Natasha K Martin 2 , 3
Tumor; pH; Acidity; Dichloroacetate; Sodium bicarbonate
Chronic oral administration of DB has no adverse systemic effects
Primary tumor growth was unaffected by treatments
Oral administration of bicarbonate and DCA-bicarbonate improves survival over DCA and untreated mice
Cytotoxic and lactate production assays suggest loss of anti-cancer efficacy of DCA in hypoxic tumors
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